While a direct link between SMN and Klf15 has currently not been demonstrated, we have previously reported the age- and tissue-dependent diurnal expression of the Smn gene alongside core clock genes in metabolic tissues of SMA mice during disease progression28, suggesting a potential functional relationship between SMN, peripheral circadian rhythms and metabolic homeostasis. The gene discussed is SMN2; the disease is proximal spinal muscular atrophy.