Conversely, among the 618 less accessible genes identified in the overlapping analysis of GS, GA and GSA (Figs. 2E, and 3B), we observed key regulators of hematopoietic development and myeloid differentiation, including GFI1B48, ITGA2B49, and EGR143, NOTCH1 and CREBBP50, as well as CUX1, a tumor suppressor frequently lost in the MDS51 (Fig. 3B and Supplementary Fig. 4B). The gene discussed is NOTCH1; the disease is neoplasm.