HOXB3 and hematologic disorder: Notably, some of the accessible chromatin regions gained in GS and GSA, but not in GA, have been linked to genes involved in hematological disorders, such as MEF2C, whose upregulation is associated with poor outcome in pediatric AML31, the leukemogenic drivers MEIS132, HOXB3, known to promote cell growth in pre- and established leukemia33; ETV6, HOXB9, LMO2 and MEIS2, transcription factors, commonly associated with AML34,35 (Figs. 2E, 3A; Supplementary Figs. 3A, B and 4A).