Similar, rapid phosphorylation of GCN2 and expression of ATF4 was observed in Dabrafenib-stimulated colorectal cancer cells, regardless of whether they exhibited paradoxical activation of ERK1/2 (HCT116 cells, KRASG13D) or inhibition of ERK1/2 (HT29 cells, BRAFV600E) (Fig. 6B). Here, EIF2AK4 is linked to colorectal cancer.