GRAMD4 and glioblastoma: This indicates that the lactylation modification of H4K16la inhibits the transcription of BEST1, GRAMD4, and MBD6. Additionally, western blot analysis revealed that the expression levels of IL-6 and IL-8 were significantly reduced after SUCLG2 knockdown, which affected GBM (Figs. 7P, S4E).