Based on the IP-MS and acetylated proteomics results, we selected LMNA as a candidate target protein because of its detection in SUCLG2 IP-MS but not in control IP-MS and its identification in IP-MS and 4D acetylation proteomics; moreover, enrichment analysis of proteins with upregulated acetylation modifications in 4D acetylation proteomics showed that these proteins mainly affected ATPase activity in the TCA, playing a key role in maintaining cell survival and tumour progression (Fig. S3A). Here, SUCLG2 is linked to neoplasm.