Additionally, the interaction between SUCLG2 and dihydrolipoamide acetyltransferase (DLAT) promoted lactate reduction, affecting H4K16la-regulated transcription of BEST1, GRAMD4, and MBD6. This inhibited the secretion of cytokines interleukin (IL)-6 and IL-8, suppressing GBM cell proliferation, increasing endoplasmic reticulum stress, leading to cell injury, mediating mitochondrial apoptosis, and resulting in increased cell death. This evidence concerns the gene DLAT and glioblastoma.