TGF-β was commonly expressed by multiple cell types (Fig. 5d), including cancer cells, stromal cells and BECs, and its expression was upregulated in metastatic LNs (Fig. 5e), potentially driving the expression of MGP, FN1, SOX4, PDPN, and HEY1 in LECs (Fig. 5c). The gene discussed is HEY1; the disease is cancer.