Our systematic comparison shows that LRRC2 has a consistent and statistically inhibitory effect in LUAD, and the expression in tumor tissues is significantly lower than that in adjacent non-tumor tissues (P < 0.0001), normal lung tissues (P < 0.0001), and the combined normal tissues (adjacent non-tumor tissues + normal lung tissues, P < 0.0001) (Supplementary Fig. 4). Here, LRRC2 is linked to neoplasm.