The results indicated that the accumulation of γ-H2AX increased after 1 hour and 24 hours of radiotherapy in CNOT7 knockdown CRC cells (Fig. 3D, E and Fig. S4A, B), while the accumulation of γ-H2AX was notably reduced in CNOT7 overexpressing cells (Fig. 3F, G and Fig. S4C, D). Here, H2AX is linked to colorectal carcinoma.