AKT1 and neoplasm: Interestingly, we found that patient tumor cells (from the NCT03197389 cohort) with a higher PI3K/AKT activation signature presented lower antigen presentation (Supplementary Fig. 5b), which is consistent with previous findings that PI3K activation suppresses antigen presentation in epithelial cells.36 We also experimentally confirmed that PI3K inhibition enhanced antigen presentation in tumor cells (Supplementary Fig. 5c).