Previous studies have indicated that FAM114A1 is involved in cardiac pathological remodeling and promotes the development of cardiovascular disease.66 In addition, preliminary correlation studies suggest that high expression of FAM114A1 is associated with a poor prognosis in cancers,67,68 and that AKT1 signaling might be involved in the tumor-promoting role of FAM114A1 in hepatocellular carcinoma.69 However, the precise molecular mechanisms governing the oncogenic functions of FAM114A1 remain poorly understood. Here, AKT1 is linked to cancer.