As a regulatory repressive subunit of PI3K, p85α binds to and inhibits p110α catalytic activity and downstream PI3K/AKT signaling.41–44 Our data, together with previous findings, suggest that FAM114A1 may disrupt the p85α/p110α complex to activate PI3K/AKT signaling, thereby suppressing antigen presentation in tumor cells. The gene discussed is AKT1; the disease is neoplasm.