ZEB2 and breast cancer: In particular, we found that the SIID-imputed expression for ZEB2, a well-known oncogenic driver implicated in epithelial-mesenchymal transition (EMT) in breast cancer (di Gennaro et al. 2018; De Coninck et al. 2019), closely mirrors the true tissue structure (R2 = 0.48) (Fig. 3C), whereas Tangram's imputed expression is more uniformly distributed across the slice (R2 = 0.29) (Fig. 3D).