An interplay exists between human genetics and intratumoral microbiota in CRC progression, where genetic variations, like a specific single nucleotide polymorphism (SNP) in the KCNJ11 gene, can alter the composition of the intratumoral microbiota by affecting bacterial adhesion and promote CRC by promoting the presence of bacteria like F. nucleatum. Here, KCNJ11 is linked to colorectal carcinoma.