The present study concentrated on the role of CentA1 in the development of AD-like phenotypes in the J20 mouse model, which has amyloid pathology, however does not have tau pathology (Mucke et al., 2000); therefore, continued investigation using other mouse models, such as the 3xTg-AD (Javonillo et al., 2021), is warranted. Here, MAPT is linked to amyloidosis.