Tea polyphenols act as natural bioactive compounds that could complement traditional therapeutic agents for neurodegenerative diseases characterized by proteostasis defects (12, 13), including Aβ (14, 15, 16), tau (17), α-synuclein (15), inflammation (18), and oxidative stress (14, 15, 16). The gene discussed is MAPT; the disease is neurodegenerative disease.