This need is further reinforced by evidence from the multinational randomised trial Safety, tolerability and efficacy of rapid optimization, helped by NT-proBNP testing, of heart failure therapies (STRONG-HF), which showed that high-intensity care with rapid uptitration of all medications included in GDMT led to better outcomes for patients hospitalised due to acute heart failure.19 The gene discussed is NPPB; the disease is hydrops fetalis.