The expression of VEGF (p<0.05) and BCL-2 (p<0.05) increased and caspase-3 (p<0.001) and IL-6 (p<0.001) genes decreased in the N20+C group when compared to the VCL group.<h4>Conclusions</h4>Naringenin has been demonstrated to reduce oxidative stress and apoptosis through the intrinsic pathway in rats with varicocele. The gene discussed is IL6; the disease is varicocele.