Following a 21-day period, the rats were euthanized, and the quality of the tissue, the level of oxidative stress, the expression levels of HSP70, and the expression levels of the genes VEGF, BCL-2, caspase-3, and IL-6 in the testes were evaluated.<h4>Results</h4>Based on H&E images, varicocele induced tissue damage was improved by Naringenin. This evidence concerns the gene CASP3 and varicocele.