The central role of multiheme c‐type cytochromes predicted by our network is supported by studies on ANME‐2a performing iron‐dependent AOM (Slobodkin et al. 2023) and Candidatus Methanoperedens performing manganese‐dependent AOM (Leu et al. 2020), both of which revealed extensive MHC expression. Here, HLA-C is linked to infectious otitis media.