MSMB and male reproductive organ cancer: Some studies reported the level of MSMB in benign prostate tissues or BPH was significantly elevated and decreased or lost in PCa (Luebke et al., 2019; Nam et al., 2006; Whitaker et al., 2010); however, others paradoxically observed that the decreased expression of MSMB was both in the tumor (especially in more advanced tumor) and adjacent benign prostate tissue (Bergström et al., 2018).