Interestingly, in patients with ischemic cardiomyopathy (ICM), SNO-BDH1 was decreased and SCoR2 levels were preserved, indicating context-specific regulation (and possibly maladaptive change; Figure 4S, T, representative SNORAC/western blot in Figure 4—figure supplement 1). The gene discussed is BDH1; the disease is ischemic cardiomyopathy.