In poly ADP-ribose polymerase (PARP) inhibitor (PARPi)–resistant ovarian cancer, lactate accumulation induced by enhanced glycolysis promotes H4K12la histone modification at the RAD23A promoter and its associated super-enhancer (Nira-SE), which facilitates MYC recruitment and drives RAD23A overexpression, ultimately enhancing DNA repair capacity and conferring niraparib resistance [193]. Here, RAD23A is linked to ovarian carcinoma.