The m6A demethylase AlkB homolog 5 (ALKBH5) is upregulated in cisplatin-resistant ovarian cancer, where it forms a positive feedback loop with the transcription factor homeobox A10 (HOXA10), and promotes resistance by demethylating JAK2 mRNA, preventing its degradation by YTHDF2 and activating the JAK2/STAT3 signaling pathway [181]. Here, JAK2 is linked to ovarian carcinoma.