AR and posterior cortical atrophy: Although LNCaP is a hormone-sensitive PCa cell line and C4-2 is a castration-resistant PCa cell line, we found that after KMT2D knockdown, AR protein levels in LNCaP and C4-2, two PCa cell lines at different stages that are dependent on the AR pathway for proliferation, were significantly reduced, being approximately 0.47- and 0.64-fold of the control levels, respectively (Fig. 1a).