Similarly, single-gene analyses indicated that in carriers positive for TM6SF2, MBOAT7, and GCKR, the association between circadian rhythm disruption and fatty liver disease was attenuated, whereas in GCKR-positive individuals, the associations between circadian rhythm disruption and cirrhosis and hepatocellular carcinoma were enhanced. The gene discussed is TM6SF2; the disease is hepatocellular carcinoma.