Intriguingly, analysis of scRNA-seq data sets from SARS-CoV-2-susceptible upper airway cells revealed higher expression of GBP5 in cells from healthy children vs healthy adults and a larger induction of GBP5 in cells from SARS-CoV-2-infected children vs infected adults (Fig. 1d; Fig. S1f), which is consistent with the recent suggestion that higher basal activity of the innate immune system in children may explain their lower SARS-CoV-2 infection rate and decreased risk of developing COVID-19 compared with adults (11). The gene discussed is GBP5; the disease is COVID-19.