GBP genes were also upregulated in SARS-CoV-2-infected human alveolar epithelial type-2 (AT2) organoids and lung tissues from COVID-19 patients, with GBP5 being highly upregulated in both cases (~44 fold and ~16 fold vs mock-infected cells and normal lung tissue, respectively; Fig. 1b and c) (28, 30). The gene discussed is GBP5; the disease is COVID-19.