Despite the absence of detectable ANA (tested by enzyme-linked immunosorbent assay (ELISA); immunofluorescence (IF) was not performed due to resource limitations), the patient exhibited strongly positive anti-double-stranded DNA antibody (anti-dsDNA) antibodies, fulfilling four American College of Rheumatology (ACR) classification criteria for SLE. Here, BTG3 is linked to systemic lupus erythematosus.