TP53 and posterior cortical atrophy: Pathogenic and likely pathogenic germline variants of TP53 have been described, including R158H, R282Q, R283C, and R337H, causing autosomal dominant cancer predisposition syndromes (Li-Fraumeni syndrome), and increasing the risk of aggressive PCa 9.1-fold (95% CI: 6.2-14; p < 0.001) relative to population controls [12].