Notably, two non-synonymous SNPs in TP53, P72R (rs1042522) and P47S (rs1800371), as well as SNPs in regulators MDM2 (rs2279744), MDM4 (rs1380576), and HAUSP/USP7 (rs1529916), have been associated with PCa development and progression [13]. The gene discussed is USP7; the disease is posterior cortical atrophy.