Maternal outcomes (M): M1: glycaemic control (HbA1c); M2: need for additional therapy/escalation (switch to insulin); M3a: SVD; M3b: IOL; M3c: elective/planned cesarean section (C-section); M3d: emergency/non-scheduled C-section; M4: hypertensive disorders; M5: maternal weight gain: M6: adverse drug effects; M7: other obstetric complications (e.g. polyhydramnios, preterm labour trigger etc.) This evidence concerns the gene INS and hypertensive disorder.