RA: rheumatoid arthritis; MTX: methotrexate; csDMARDs: conventional synthetic disease-modifying antirheumatic drugs; CDAI: Clinical Disease Activity Index; ACR: American College of Rheumatology; DAS28-CRP: disease activity score based on 28 joints with C-reactive protein; HAQ-DI: Health Assessment Questionnaire-Disability Index; TEAEs: treatment-emergent adverse events; TJC: tender joint count; SJC: swollen joint count; VAS: visual analog scale; JAKi: Janus kinase inhibitors. The gene discussed is CRP; the disease is rheumatoid arthritis.