As the patient presented with CVID and unexplained systemic inflammation, targeted next-generation sequencing of known CVID-related genes (ICOS, TNFRSF13B, CD19, TNFRSF13C, MS4A1, CD81, CR2, LRBA, NFKB2, IL21, NFKB1, IKZF1, PLCG2, CTLA4, and MSN) was performed at the Kazusa DNA Research Institute (Kisarazu, Chiba, Japan), which identified no pathogenic mutations. The gene discussed is PLCG2; the disease is common variable immunodeficiency.