CD8A and lung cancer: Furthermore, defects in autophagy-related genes (ATG) significantly impact CD8+ T cell function: Atg5/Atg7 deficiency enhances CD8+ T cell infiltration and IFN-γ secretion, while Atg4/Atg5 knockdown upregulates MHC-I expression and antigen presentation in lung cancer cells; while Atg7 deficiency suppresses tumor cells through metabolic promotes CD8+ T cell accumulation in the colonic lamina propria (92–94).