Mitochondria-targeted drugs can activate the cGAS-STING pathway, promote DAMPs release, induce ferroptosis, and regulate immune cell activity by producing MTROS, reducing δψm, triggering endoplasmic reticulum stress or Lipid peroxidation, etc. The reduction of immunosuppressive cells will ultimately improve the efficacy of tumor immunotherapy. Here, STING1 is linked to neoplasm.