CD8A and breast cancer: Clinical studies reveal that LC3B expression in hypopharyngeal squamous cell carcinoma (HSCC) positively correlates with CD8+/CD39+ T cell infiltration, while LC3B deficiency in breast cancer reduces CD8+ T cell infiltration and increases FOXP3+ Treg/CD68+ macrophage numbers, suggesting autophagy influences tumor prognosis by regulating CD8+ T cell infiltration (95).