Ionizing radiation can damage the mitochondria of tumor cells such as colon cancer, lung cancer and T lymphoma, resulting in the release of mtDNA, which is phagocytosed by DC cells and activates the cGAS-STING signaling pathway, enhancing the ability of DC cells to deliver antigens to CD8+ T cells, and ultimately enhancing tumor immunity (79). Here, CD8A is linked to lung carcinoma.