In addition, the subgroup analyses (Supplementary Figure S1) based on HBV status, cirrhosis severity, and systemic agents demonstrated that the prognostic effect of TRG was consistent and significant (log-rank P < 0.05 for TRG1 vs. TRG2 or TRG3; log-rank P > 0.05 for TRG2 vs. TRG3 in all subgroups). The gene discussed is SAMM50; the disease is Cirrhosis.