MAP3K5 and primary biliary cholangitis: In addition, the TNFRSF19, ASK1, p-p38, and fibrosis indices in liver tissue were basically consistent with the cellular results, indicating that exosomal miR-122-5p does indeed target TNFRSF19 to regulate the ASK1 level and alleviate the pathological damage of liver tissue in PBC mice via the p38MAPK signaling pathway (Figure 14).