Studies have shown that orally administered periodontal pathogen Porphyromonas gingivalis can enter the gut through the digestive tract, causing gut microbiota dysbiosis and systemic inflammation, downregulating genes that improve insulin sensitivity in AT (C1qtnf9, Irs1, and Sirt1), and upregulating genes related to lipid droplet formation and gluconeogenesis (Plin2, Acox, and G6pc), inducing insulin resistance and increasing susceptibility to periodontitis. Here, INS is linked to periodontitis.