FCGR3A and anemia (phenotype): Protection from anemia was associated with immune cell activation via FcγRIIIa, rather than complement-mediated lysis, likely due to the uneven distribution of PfEMP1 on IEs (120), suggesting that Fc-afucosylation enhances antibody function by improving IgG binding to FcγRIIIa, which boosts NK cell activation and IE clearance.