PROCR and retinal disorder: (98) reported that among children with CM, those with retinopathy had significantly lower IgG responses to the EPCR-binding CIDRα1.4 than children without retinopathy, even though the expression of var genes encoding CIRDα1.4 binding domains and in vitro cytoadherence levels of isolated IEs to EPCR were similar between the groups (98).