FLG and Eczematoid dermatitis: The pathogenesis of eczema arises from complex interactions among genetic susceptibility (e.g., filaggrin (FLG) mutations), impaired skin barrier function (e.g., elevated pH and microbial dysbiosis), dysregulated immune responses (including Th2/Th17 imbalance), and environmental factors (1, 4, 7, 8).