IL4 and Eczematoid dermatitis: Mechanistic level: PRP significantly upregulates growth factor expression in eczema models, promotes KCs proliferation and ECM synthesis (barrier repair); suppresses Th2/Th17 cytokines (IL-4, IL-17) and upregulates Treg proportion and IL-10 (immunomodulation); reduces S. aureus load and biofilm formation (antimicrobial activity); decreases IL-1β, TNF-α, and NGF (inflammation and neuroregulation); and improves stratum corneum hydration and TEWL (hydration enhancement).