Immune signaling pathways function as microbial sensors; the deletion of MyD88 in intestinal epithelial cells reconfigures the microbiota by increasing anti-inflammatory endocannabinoids and regenerating islet-derived protein 3 gamma (Reg3γ), thereby providing protection against diet-induced metabolic disease, effects that are transferable through fecal transplant (49). The gene discussed is MYD88; the disease is Other metabolic disease.