One way that the NLRC4 inflammasome and its augmentation by LRRK2 could have a particular effect on Crohn’s inflammation is related to the fact that this inflammasome is present in gut epithelial cells and is known to play a key role in host defense against infection with Salmonella (and perhaps other pathogens) via induction of epithelial cell-related organism expulsion (42). This evidence concerns the gene NLRC4 and infection.