However, B cells can also drive immunosuppression through distinct mechanisms, such as IL-21 receptor signaling inducing immunosuppressive IgA+ B cells to inhibit CD8+ T cell activity, or Ten-eleven translocation methylcytosine dioxygenase 2-mediated IL-10+ regulatory B cells (Breg) promoting tumor immune evasion (118). Here, CD8A is linked to neoplasm.