(44, 45) demonstrated that 2 Hz EA significantly suppressed the expression of high mobility group box 1 (HMGB1), Toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), and NF-κB p65 proteins in both the spinal cord and dorsal root ganglion in a spared nerve injury (SNI)-induced neuropathic pain rat model. This evidence concerns the gene HMGB1 and neuropathic pain.