IL22 and cervical disk degenerative disorder: (51) showed that EA treatment significantly downregulated the mRNA expression of Interleukin-22 (IL-22), JAK2, and STAT3, and suppressed the levels of their phosphorylated proteins (p-JAK2, p-STAT3) in the nucleus pulposus tissue of a rat model of cervical intervertebral disc degeneration (CIDD).