CREB5 and Sepsis: For example, studies have found that miR-582-5p/miR-590-5p can induce monocyte immunosuppression by targeting the CREB1/CREB5-NF-κB signaling pathway cascade that ultimately drives monocytic immunosuppression (55), suggesting that CREB5 may act as a regulator of the immune imbalance characteristic of sepsis.