RanBALL achieved a perfect or very high accuracy for the majority of the 20 B-ALL subtypes, including PAX5alt (100%), KMT2A Group (100%), DUX4 (100%), TCF3-PBX1 (100%), Low hypodiploid (100%), MEF2D (100%), PAX5 P80R (100%), BCL2/MYC (100%), HLF (100%), ETV6-RUNX1 (98.2%), High hyperdiploid (97.5%), Ph-like (94.8%), ZNF384 Group (93.8%), ETV6-RUNX1-like (91.7%), Low hyperdiploid (86.7%), and Ph (80.6%). This evidence concerns the gene DUX4 and acute lymphoblastic leukemia.