Chromosome 9 open reading frame 72 (C9orf72), TAR DNA-binding protein (TARDBP), superoxide dismutase 1 (SOD1), and fused in sarcoma (FUS) are essential genes frequently linked to the pathophysiology of ALS, all of which are involved in the dysregulation of RNA metabolism. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.