PTPN21 and atherosclerosis: Several additional targets exhibited consistent downregulation across atherosclerosis datasets, including genes involved in cytoskeleton organization and actin dynamics (Limch1, Kif1c, Aif1l, Ptpn21), signal transduction as kinases or receptors (Plxna4, Fgfr2, Gpsm1, Ntrk3), transcriptional regulation (Npas2, Gpn1), and ion transport modulation (Fxyd7, a regulator of Na+/K+-ATPase activity).