The Metformin in Gestational Diabetes: The Offspring Follow-Up (MiG TOFU) study (Australian New Zealand Clinical Trials Registry number: ACTRN12605000311651) followed up children from Auckland and Adelaide cohorts at 2 and at 7–9 years after in utero exposure to metformin for GD treatment.85,86 At the 2-year follow-up, children exposed to metformin showed higher subcutaneous fat measurements, such as increased mid-upper arm circumferences and skinfold thickness, than those born to mothers treated with insulin. The gene discussed is INS; the disease is gestational diabetes.