INS and polycystic ovary syndrome: However, despite this slowdown, insulin secretion remained partially preserved at high glucose levels.75 Foetal insulin levels were, however, not affected by metformin exposure in PCOS pregnancies.76 Whether reduced foetal growth and lower neonatal hypoglycaemia, alongside higher rates of SGA infants, reflect metformin’s impact on foetal insulin secretion remains a hypothesis that warrants further exploration.