INS and type 2 diabetes mellitus: The Metformin in women with type 2 diabetes in pregnancy (MiTy) trial (Metformin in Women With Type 2 Diabetes in Pregnancy Trial; ClinicalTrials.gov identifier: NCT01353391) investigated the effects of adding metformin to a standard insulin regimen.22 The study concluded that metformin-exposed infants had a lower mean birth weight, were less likely to have a birth weight >97th percentile and had reduced adiposity measures.