The heparin‐binding growth factor midkine promotes tumor invasion [48] and metastasis by activating the PI3K/Akt [49] and MAPK/ERK [50] pathways, driving tumor cell survival, proliferation, and DNA damage repair while inducing the EMT [51] via the Snail–N‐cadherin axis, leading to epithelial marker loss and mesenchymal marker gain. This evidence concerns the gene CDH2 and neoplasm.