Factor Xa inhibitor overdose demonstrated a trend toward association with HE (p = 0.089), whereas the type of Xa inhibitor (p = 0.200), sBP on admission (p = 0.245), initial hematoma volume (p = 0.737), and platelet count (p = 0.766) were not predictive. This evidence concerns the gene TNXA and hereditary elliptocytosis.