RORA and autism: These findings are significant because studies on the RORαsg mice indicate that RORα protein is involved in several processes relevant to autism including Purkinje cell differentiation (Hadj-Sahraoui et al., 2001; Boukhtouche et al., 2006b; Chen et al., 2013), cerebellar development (Gold et al., 2003; Harding et al., 1997), brain lipid homeostasis (Chen et al., 2020), protection against oxidative stress and inflammation (Boukhtouche et al., 2006c; Delerive et al., 2001; Nejati Moharrami et al., 2018; Yue et al., 2020), and the circadian rhythm (Fatemi et al., 2012).