Particularly, keloid growths have shown the upregulation of tumor growth factor-beta/Smad and MAPK/ERK pathways as well as proto-oncogenes such as c-jun and c-fos.10 Given a potential quasi-cancerous fibroproliferative mechanism of keloids, it could be theorized that hydroxyurea halts the G0-G1 transition by preventing the formation of new DNA precursor molecules, inducing keloid fibroblast apoptosis. This evidence concerns the gene JUN and keloid.