TARDBP and frontotemporal dementia: Aggregations of Fused in Sarcoma (FUS) and transactive response DNA binding protein 43 (TDP-43) are predominantly associated with ALS, whereas Tau hyperphosphorylation and aggregation, often with accompanying TDP-43 aggregation, is linked to the pathology of FTD (Neumann et al., 2009a; Zhou and Xu, 2023).