METTL3 and acute myeloid leukemia: Despite their potent enzymatic inhibition against METTL3, much higher concentrations of STM2457 and UZH2 (IC50s at 1.52 μM (HeLa cells) and 0.85 μM (MOLM-13 cells), respectively) were required to achieve anti-proliferative effects in human AML cell lines and reduction of m6A/A in polyadenylated RNA in MOLM-13 cells.