NUCLEOLIN and neoplasm: These chimeric constructions include aptamer-small interfering RNA (siRNA) conjugates: (1) the PDGFRβ-targeting Gint4.T aptamer delivers STAT3 siRNA to GBM cells, achieving significant gene knockdown and tumor growth inhibition,49 and (2) AS1411 and a CpG ODN targeting nucleolin and TLR9 deliver siRNA to osteopontin.50