Besides the earlier examples (EGFRvIII, PDGFRβ, etc.), aptamers have been developed against other glioma markers like Axl (a receptor tyrosine kinase), IL-6 (a cytokine in the tumor microenvironment), and extracellular matrix components, demonstrating the adaptability of aptamers to different targets.58 The gene discussed is PDGFRB; the disease is neoplasm.