Due to its cortical connections, the MeD is a part of complex circuits involved in executive, cognitive and emotional processes.33 Similarly, the AV is a limbic subregion connected with the hippocampal formation and the amygdala,41 structures which also exhibit prominent atrophy in symptomatic GRN mutation carriers.9 Similarly to the AV, the LD is a limbic subregion with connections with the hippocampal formation,33 which is amongst the earliest4,7,9 and most severely9 affected regions in MAPT mutation carriers. Here, MAPT is linked to Atrophy.