Imaging studies have shown in vivo that thalamic subregional volumes are reduced across the clinical, pathological and genetic forms of FTD at the symptomatic stage with variable atrophy patterns.7,8 In addition, thalamic subregional atrophy is already present at an early presymptomatic stage in C9orf72 repeat expansion carriers, most prominently in the pulvinar region.7,9,10. This evidence concerns the gene C9orf72 and frontotemporal dementia.