Compared with the patients in the LOT2D group, the duration of diabetes, NHHR, the proportion of smokers, the prevalence of diabetic nephropathy, BMI, FBG, HbA1c, ALT, ALB, GGT, UA, TG, WBC, N, and PLT levels were significantly higher in the EOT2D group (P < 0.05), and HDL-C was lower than in the LOT2D group (P < 0.05) (Table 1). This evidence concerns the gene ALB and diabetes mellitus.